Table 6.
Result of multivariate tests for interactions of the ‒493G/T SNP in the MTTP gene (in different genetic models) with characteristics of interest that influence the presence of hepatic steatosis in patients with chronic hepatitis C.
| Parameter | OR | 95% CI | pa |
|---|---|---|---|
| Dominant model | |||
| Sex (female) | 1.94 | 1.07‒3.50 | 0.028 |
| HOMA-IR (≥3) | 1.87 | 1.01‒3.47 | 0.048 |
| HCV genotype 3 | 0.73 | 0.22‒2.40 | 0.601 |
| Inflammatory activity (A2‒A3) | 4.75 | 2.51‒8.97 | < 0.001 |
| -493G/T SNP (GT/TT) | 0.66 | 0.35‒1.24 | 0.193 |
| -493G/T SNP (GT/TT) × HCV genotype 3 | 11.51 | 2.08‒63.59 | 0.005 |
| Codominant model | |||
| Sex (female) | 1.92 | 1.06‒3.49 | 0.031 |
| HOMA-IR (≥3) | 1.88 | 1.00‒3.50 | 0.048 |
| HCV genotype 3 | 0.72 | 0.22‒2.40 | 0.597 |
| Inflammatory activity (A2‒A3) | 4.94 | 2.60‒9.40 | < 0.001 |
| -493G/T SNP (GG) | |||
| GT | 0.56 | 0.29‒1.10 | 0.091 |
| TT | 1.25 | 0.42‒3.75 | 0.690 |
| -493G/T SNP (GG) × HCV genotype 3 | |||
| -493G/T SNP (GT) × HCV genotype 3 | 15.69 | 2.46‒99.85 | 0.004 |
| -493G/T SNP (TT) × HCV genotype 3 | 3.64 | 0.23‒56.51 | 0.356 |
| Recessive model | |||
| Sex (female) | 2.08 | 1.16‒3.73 | 0.014 |
| HOMA-IR (≥3) | 1.71 | 0.93‒3.15 | 0.084 |
| HCV genotype 3 | 2.78 | 1.27‒6.11 | 0.011 |
| Inflammatory activity (A2‒A3) | 4.52 | 2.43‒8.39 | < 0.001 |
| -493G/T SNP (GG/GT) | 1.62 | 0.62‒4.22 | 0.327 |
a
Multiple logistic regression. When interaction is placed, only the interaction should be interpreted. The significance level of p < 0.05 is marked in bold font.
CI, Confidence Interval; HCV, Hepatitis C Virus; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; OR, Odds Ratio; SNP, Single Nucleotide Polymorphism.