Table 9.
Result of multivariate tests for interactions of the Q244E SNP in the MTTP gene (in different genetic models) with characteristics of interest that influence the presence of hepatic steatosis in patients with chronic hepatitis C.
| Parameter | OR | 95% CI | pa |
|---|---|---|---|
| Sex (female) | 2.05 | 1.14‒3.67 | 0.016 |
| HOMA-IR (≥3) | 1.73 | 0.94‒3.18 | 0.079 |
| HCV genotype | 2.82 | 1.29‒6.17 | 0.009 |
| Inflammatory activity (A2‒A3) | 4.52 | 2.44‒8.39 | <0.001 |
| Q244E SNP (QE × EE)b | 1.29 | 0.50‒3.31 | 0.597 |
a
Multiple logistic regression. When interaction is placed, only the interaction should be interpreted. Significance level of p < 0.05.
b
No patients presented the QQ genotype.
CI, Confidence Interval; HCV, Hepatitis C Virus; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; OR, Odds Ratio; SNP, Single Nucleotide Polymorphism.