Table 1.
Morphology | Immunohistochemistry | Molecular | Location/age/sex | |
---|---|---|---|---|
Case 1 | Biphasic; SFT-like stroma with primitive round cell, neuroepithelial with neurofibrillary-like matrix, and carcinoma components; rhabdomyosarcomatous differentiation in both the spindled and primitive round cell components |
Positive STAT6 + in stromal components only; Pancytokeratin (+ in squamous elements only); Nuclear Beta-catenin positivity (in squamous elements only) |
NAB2::STAT6 CCND1, CTNNB1, PRKCB mutations |
Right nasal/30/M |
Case 2 | Biphasic; SFT-like stroma with neuroepithelial with neurofibrillary-like matrix and squamoid carcinoma components |
Positive STAT6 + in stromal components only; CD34 (weakly + in stroma); Pancytokeratin (in epithelial elements only); Negative S100, Desmin, beta-catenin (membranous in all components), SMARCA4 (intact) |
NAB2::STAT6 BRCA2, BUB1B, LTBP1, NF1 mutations |
Left nasal/54/F |
F female, M male, SFT solitary fibrous tumor