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. 2022 Mar 18;16(3):746–754. doi: 10.1007/s12105-022-01444-7

Table 1.

Summary of NAB2::STAT6-containing neoplasms with sinonasal teratocarcinosarcoma-like morphology

Morphology Immunohistochemistry Molecular Location/age/sex
Case 1 Biphasic; SFT-like stroma with primitive round cell, neuroepithelial with neurofibrillary-like matrix, and carcinoma components; rhabdomyosarcomatous differentiation in both the spindled and primitive round cell components

Positive

STAT6 + in stromal components only;

Pancytokeratin (+ in squamous elements only);

Nuclear Beta-catenin positivity (in squamous elements only)

NAB2::STAT6

CCND1, CTNNB1, PRKCB mutations

Right nasal/30/M
Case 2 Biphasic; SFT-like stroma with neuroepithelial with neurofibrillary-like matrix and squamoid carcinoma components

Positive

STAT6 + in stromal components only;

CD34 (weakly + in stroma);

Pancytokeratin (in epithelial elements only);

Negative

S100, Desmin, beta-catenin (membranous in all components), SMARCA4 (intact)

NAB2::STAT6

BRCA2, BUB1B, LTBP1, NF1 mutations

Left nasal/54/F

F female, M male, SFT solitary fibrous tumor