Table 2.
The multivariate regression for development of ACLF in patients with HBV-related decompensated cirrhosis in the derivation cohort.
| Characteristics | HR (95% CI) | p value |
|---|---|---|
| Demographic data | ||
| ln (Age) | 2.71 (0.89-5.86) | 0.074 |
| Precipitant events | ||
| Hepatitis B flare with HBV reactivation | 2.39 (1.34-4.26) | 0.003 |
| Spontaneous hepatitis B flare with high HBV-DNA load | 2.09 (1.10-3.97) | 0.024 |
| Superimposed infection on HBV | 4.19 (1.85-9.46) | 0.001 |
| Hepatotoxic drugs | 1.60 (0.73-3.51) | 0.245 |
| Bacterial infection | 3.59 (1.31-9.84) | 0.013 |
| Variceal bleeding | 2.18 (0.85-5.57) | 0.103 |
| Disease severity parameter | ||
| ln (TB) | 2.68 (1.82-3.94) | <0.001 |
| ln (INR) | 38.72 (13.92-107.71) | <0.001 |
| ln (Hemoglobin) | 0.79 (0.23-2.68) | 0.706 |
| ln (Sodium) | 0.39 (0-165.7) | 0.759 |
| Ascites | 2.27 (0.84-6.17) | 0.108 |
| AD number | 0.34 (0.05-2.16) | 0.252 |
| Systemic inflammatory | ||
| ln (WBC count) | 0.67 (0.42-1.07) | 0.096 |
| ln (NL ratio) | 1.69 (1.16-2.45) | 0.006 |
HR, hazard ratio; INR, International normalized ratio; NL ratio, neutrophil-lymphocyte ratio; TB, total bilirubin; WBC, white blood cell.