FIGURE 1.

Schematic of the mutational events around the Cyp6aa/Cyp6p cluster on chromosome 2R in Anopheles gambiae. Upper panel shows the three mutational events observed in east and central African samples. Orange indicates the genes/transposable elements involved and the blue band the extent of the Cyp6aap‐Dup1 CNV. The lower panel, redrawn from Lucas et al. (2019), shows the genomic extent and geographic distribution of the CNVs that have been observed around the Cyp6aa/Cyp6p cluster, 13 out of 15 include Cyp6aa1.The dark blue shading on the map indicates the geographic extent of Cyp6aap‐Dup1. Data from Uganda, Kenya and DRC are reported extensively in the main text, in addition 27.4% (n = 84) of Anopheles gambiae females sampled from northern Tanzania in 2018 were triple mutant carriers