Table 1.
Demographics and clinical characteristics of patients with pedullary thyroid cancer.
| Demographic or Characteristic | Primary Cohort | Validation Cohort | |||||
|---|---|---|---|---|---|---|---|
| N0+N1a (n=35) | N1b (n=47) | Total (n=82) | N0+N1a (n=20) | N1b (n=22) | Total (n=42) | ||
| Age (years, mean ± SD) | 47.6 (13.6) | 46.6 (12.6) | 47.0 (13.0) | 45.3 (12.5) | 50.8 (16.0) | 48.2 (14.5) | |
| Sex | Male (%) | 8 (22.9) | 29 (61.7) | 37 (45.1) | 6 (30.0) | 14 (63.6) | 20 (47.6) |
| Female (%) | 27 (77.1) | 18 (38.3) | 45 (54.9) | 14 (70.0) | 8 (36.4) | 22 (52.4) | |
| Ultrasound | Maximum tumor diameter (cm, median, IQR) | 1.3 (0.8-2.3) | 2.2 (1.3-3.4)# | 1.8 (1.1-2.9) | 1.3 (1.0-2.3) | 2.3 (1.6-3.6) | 1.8 (1.1-2.8) |
| Multiple foci (%) | 3 (8.6) | 16 (34.0) | 19 (23.2) | 4 (20.0) | 6 (27.3) | 10 (23.8) | |
| Bilateral lesions (%) | 4 (11.4) | 8 (17.0) | 12 (14.6) | 2 (10.0) | 1 (4.5) | 3 (7.1) | |
| Central LNM (%) | 1 (2.9) | 26 (55.3) | 27 (32.9) | 1 (5.0) | 10 (45.5) | 11 (26.2) | |
| Lateral LNM (%) | 1 (2.9) | 33 (70.2) | 34 (41.5) | 0 (0.0) | 18 (81.8) | 18 (42.9) | |
| Preoperative basal serum calcitonin (pg/mL, median, IQR) | 233.0 (77.0-622.0) | 2000.0 (901.0-4880.0) | 941.5 (236.0-2970.5) | 279.6 (84.5-549.5) | 1979.0 (936.3-4280.5) | 924.6 (254.6.-2820.3) | |
| Extent of neck dissection (%) | Central dissection | 35 (100.0) | 47 (100.0) | 82 (100.0) | 20 (100.0) | 22 (100.0) | 42 (100.0) |
| Ipsilateral lateral dissection | 10 (28.6) | 44 (93.6) | 54 (65.9) | 1 (5.0) | 22 (100.0) | 23 (54.8) | |
| Contralateral lateral dissection | 3 (8.6) | 30 (63.8) | 33 (40.2) | 0 (0.0) | 13 (59.1) | 13 (31.0) | |
| Number of LNMs (pathology, mean ± SD) | Central compartment | 0.4 (1.1) | 7.9 (8.2) | 4.7 (7.2) | 1.2 (2.2) | 5.0 (3.2) | 3.1 (3.3) |
| Ipsilateral lateral compartment | / | 11.4 (12.2) | 6.5 (10.8) | / | 12.5 (9.8) | 6.6 (9.5) | |
| Contralateral lateral compartment | 4.0 (10.3) | 2.3 (8.0) | 1.6 (3.4) | 0.8 (2.6) | |||
| Total | 0.4 (1.1) | 23.3 (26.0) | 13.5 (22.6) | 1.2 (2.2) | 19.1 (11.7) | 10.5 (12.4) | |
LN, lymph nodes; LNM, lymph node metastasis.
#A missing value.