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. 2022 Aug 16;13:979939. doi: 10.3389/fphar.2022.979939

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Copyright © 2022 Li, Liu, Luo and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FIGURE. 1 — Z1456467176 inhibits ATP-induced P2X7R pore formation. (A) Representative flow diagram of EB uptake by HEK-293T cells overexpressing hP2X7R in response to ATP. The red Q1-UR region reflects double-positive staining for EB and hP2X7R. FACS analysis of the intracellular fluorescence intensity (B) and mean value analysis of quantified intracellular fluorescence intensity (C). Data are presented as the means ± S.E.M.s. Statistics were analyzed using Dunnett’s t-test. ***p < 0.001.