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Z1456467176 inhibits BzATP-induced IL-1β secretion in macrophages. ELISA of IL-1β in supernatants from LPS (50 ng/ml)-primed THP-1 cells (A) and BMDMs (B) treated with various doses of Z1456467176 (1/10/50/100 μM) for 30 min and then stimulated with BzATP (100 μM). (C) Chemical structure of Z1456467176. Data are presented as means ± S.E.M. Statistics were analyzed using Dunnett’s t-test. n = 3. **p < 0.01; ***p < 0.001.
