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. 2022 Aug 16;13:979939. doi: 10.3389/fphar.2022.979939

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Copyright © 2022 Li, Liu, Luo and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FIGURE. 3 — Z1456467176 inhibits the P2X7R-NLRP3-IL-1β pathway in vitro. (A) WB of NLRP3, caspase-1 (p20), and IL-1β in lysates from LPS-primed PBMCs of gout patients treated with Z1456467176 (10, 50 μM) for 30 min and stimulated with BzATP (100 μM). (B–D) ELISA of IL-1β, TNF-α, and IL-6 in culture supernatants from LPS-primed PBMCs of gout patients treated with Z1456467176 for 30 min and stimulated with BzATP. Data are presented as the means ± S.E.M.s. Statistics were analyzed using Dunnett’s t test. n = 3. ***p < 0.001.