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. 2022 Aug 16;13:979939. doi: 10.3389/fphar.2022.979939

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Copyright © 2022 Li, Liu, Luo and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FIGURE. 6 — Z1456467176 alleviates gouty arthritis in rats. (A) Representative MRI images of the right ankle joint of rats. The white portion reflects the degree of inflammatory edema. (B) Representative images of pathological H&E staining of the right ankle joint of rats (×200). The white arrow points to inflammatory cell infiltration in the synovial tissue of the ankle joint. (C) Equal-sized areas were taken from each group in (B) for quantification of inflammatory cells. (D) MPO activity of ankle joint homogenates. Data are presented as the means ± S.E.M.s. Statistics were analyzed using the independent samples t test or Dunnett’s t test. *p < 0.05; **p < 0.01; ***p < 0.001.