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. 2022 Jul 22;11(4):673–682. doi: 10.1093/toxres/tfac043

Fig. 1.

Fig. 1

TAM aggravated hepatic steatosis in HFD rats. A) Body weight change of animals. B) Effects of TAM on liver, periuterine, and ventral dorsal fat coefficients of HFD rats. C) Effect of TAM on serum TC, TG, HDL-c, LDL-c, VLDL, and NEFA of rats among different groups. D) Effect of TAM on hepatic TC and TG levels. E) Histopathological view of rat livers via oil red O staining: (a) CD-control, (b) HFD-control, (c) HFD-TAM-L (4 mg/kg), (d) HFD-TAM-H (8 mg/kg); oil red O sections were photographed at original 200 × magnification. F) Serum AST, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured among groups. The rats were treated with TAM (4, 8 mg/kg) intragastrically or not after CD or HFD for 15 weeks. The data are the mean ± SEM (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 compared to the CD-control group. #P < 0.05, ##P < 0.01, ###P < 0.001 compared to the HFD-control group.