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. 2022 Jul 22;11(4):673–682. doi: 10.1093/toxres/tfac043

Fig. 3.

Fig. 3

TAM downregulated the expression of SIRT1 in vivo and in vitro. A) The protein expression of SIRT1 was investigated by western blot. B) Cells viability in different TAM concentrations. ****P < 0.0001 compared to the control group. C) Intracellular TG levels of HepG2 cells. **P < 0.01 compared to the OA group. D) The protein expression of SIRT1 in HepG2 cells. *P < 0.05 compared to the OA group. Band intensity was quantified by densitometry analysis. The HepG2 cells were treated with corresponding concentration of TAM for 72 h. The rats were treated with TAM (4, 8 mg/kg) intragastrically or not after CD or HFD for 15 weeks. The results are the mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 compared to the CD-control group. #P < 0.05, ##P < 0.01, ###P < 0.001 compared to the HFD-control group.