Fig. 4.

SRT1720 attenuated TAM-induced hepatic steatosis. A) The SRT1720 chemical structure. B) The protein expression of SIRT1 was investigated by western blot. C) Histopathological view of rat livers via oil red O staining: (a) control, (b) TAM, (c) TAM + SRT1720 (15 mg/kg), (d) TAM + SRT1720 (30 mg/kg); oil red O sections were photographed at original 200 × magnification. D) Hepatic levels of TC and TG in rats. E) Serum ALT, AST were measured among groups. The rats were treated with TAM (8 mg/kg) or TAM combined with SRT1720 (15 mg/kg or 30 mg/kg) after 15 weeks of HFD. The data are the mean ± SEM (n = 6). ^*P < 0.05, ^**P < 0.01 compared to the control group. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 compared to the TAM treatment group.