Fig. 5.

SRT1720 alleviated TAM-induced changes of lipid synthetases instead of lipid transporters. A) The protein expressions of SREBP1c and CHREBP were investigated by western blot. B) Serum TC, TG, HDL-c of rats among different groups. C) The protein expressions of CD36 and MTTP were investigated by western blot. Band intensity was quantified by densitometry analysis. The rats were treated with TAM (8 mg/kg) or TAM combined with SRT1720 (15 or 30 mg/kg) after 15 weeks of HFD. The data are the mean ± SEM (n = 6). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 compared to the control group. ^###P < 0.001 compared to the TAM treatment group.