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. 2022 Aug 16;13:907980. doi: 10.3389/fphar.2022.907980

FIGURE 4.

FIGURE 4

Application of Z-DEVD-FMK and INF39 suppressed caspase-3 and NLRP3 expression. (A) Effects of Z-DEVD-FMK on NLRP3, GSDME and caspase-3 expression induced by UA. NRK-52E cells in 6-well plates were treated with Z-DEVD-FMK and UA for 24 h. (B) Statistical analyses of caspase-8, caspase-3, NLRP3, and GSDME expression (means ± SD, n = 3 in each group) after treatment of cells with Z-DEVD-FMK and UA. All data were corrected with respect to the control group. ∗∗p < 0.01 versus the model group (UA in 640 μg/ml); ∗p < 0.05 versus the model group (UA in 640 μg/ml). (C) Effects of INF39 on NLRP3, GSDME, and caspase-3 expression induced by UA. NRK-52E cells in 6-well plates were treated with INF39 and UA for 24 h. (D) Statistical analyses of caspase-8, caspase-3, NLRP3, and GSDME (means ± SD, n = 3 in each group) after treatment of cells with INF39 and UA. All data were corrected with respect to the control group. ∗∗∗p < 0.001 versus the model group (UA in 640 μg/ml); ∗∗p < 0.01 versus the model group (UA in 640 μg/ml); ∗p < 0.05 versus the model group (UA in 640 μg/ml).