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. 2022 Aug 16;9:943384. doi: 10.3389/fmolb.2022.943384

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Copyright © 2022 Huang, Dong, Zhang, Fu, Lv and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between significant prognostic ephrin members and immune checkpoint-related genes in HCC. (A) Heatmap displaying the coexpression relationship between prognosis-related ephrins and 47 immune checkpoint-related genes. (B–D) Scatterplots displaying the association of EFNA3 (B), EFNA4 (C), and EFNB1 (D) expression with four key immune checkpoint-related genes (PDCD1, CTLA4, CD274, and PDCD1LG2) with Spearman correlation analysis. r: Spearman’s rank coefficient; *p < 0.05; **p < 0.01.