. 2022 Aug 17;37(33):e255. doi: 10.3346/jkms.2022.37.e255

Table 3. List of patients who had maximum alanine aminotransferase ≥ 200 IU/L during angiotensin-II receptor blocker therapy with high probability of drug induced liver injury (RUCAM score ≥ 6).

#	Age	Sex	ARB	Dose	Duration, days	Baseline ALT, IU/L	Peak ALT, IU/L	AST^a, IU/L	Albumin^a, g/dL	Bilirubin^a, mg/dL	ALP^a, IU/L	GGT^a, IU/L	Statin	Metformin	DM	Fatty liver	RUCAM	Department
1	62	2	Fimasartan	30	88	35	383	324	4.7	1.3	97		Y	Y	Y	N	10	IMC
2	64	1	Fimasartan	120	12	44	419	351	3.5	0.7	118		Y	Y	Y	N	10	Others
3	72	2	Fimasartan	60	48	37	2,394	1,380	3.9	1.4	268	200	Y	N	N	N	10	NR
4	35	1	Fimasartan	60	146	39	218	110	4.7	0.9	75	33	Y	N	N	Y	9	IMC
5	47	1	Fimasartan	120	337	18	631	303	4.5	1.0	93	93	Y	N	N	N	9	IMC
6	49	2	Fimasartan	120	105	37	226	82	3.8	0.5	175	327	Y	N	N	Y	9	IMN
7	66	2	Fimasartan	60	91	41	300	211	3.2	1.0	64	204	N	N	N	-	8	NR
8	42	1	Fimasartan	30	212	59	260	105	4.7	1.5	49	58	N	N	N	Y	6	IMC
9	56	2	Fimasartan	30	105	19	840	434	3.2	0.7	118		Y	N	N	N	6	IMN
10	59	1	Fimasartan	120	92	22	351	125	4.3	1.1	115		Y	Y	Y	-	6	IMC
11	77	2	Fimasartan	120	196	12	241	267	3.8	0.5	68	43	Y	N	N	N	6	IMN
12	71	2	Candesartan	8	21	39	212	221	3.8	0.5	103		Y	N	Y	N	10	IMC
13	59	2	Candesartan	8	241	24	220	159	3.9	0.8	57		Y	N	N	N	6	IMC
14	58	1	Candesartan	16	298	6	629	299	4.0	0.9	310		Y	N	Y	N	6	IMN
15	77	2	Candesartan	8	157	33	335	185	4.0	0.4	56		Y	Y	Y	-	6	IMN
16	79	2	Candesartan	8	31	86	219	53	2.8	0.7	81	44	Y	N	N	-	6	NS
17	71	2	Valsartan	80	66	46	706	866	3.3	10.4	334	363	Y	N	N	-	6	IMC
18	66	1	Valsartan	80	861	24	1,570	1,480	3.3	14.1	268	114	Y	N	N	-	7	IMC
19	78	2	Valsartan	80	360	89	248	192	4.3	0.8	91	31	N	N	Y	Y	6	IME
20	60	2	Valsartan	80	55	12	206	117	4.5	0.4	60	12	Y	Y	Y	-	7	IMC

ARB = angiotensin-II receptor blocker, ALT = alanine aminotransferase, AST = aspartate aminotransferase, ALP = alkaline phosphatase, GGT = gamma-glutamyl transferase, DM = diabetes mellitus = RUCAM = Roussel Uclaf Causality Assessment Method, Y = yes, N = no, IMC = cardiology, NR = neurology, IMN = nephrology, NS = neurologic surgery, IME = endocrinology.

^aData obtained the same date of maximum ALT.