Table 5. Multivariable cox analysis for the development of significant ALT elevation (> 120 IU/L) during ARB therapy.

Variables		HR (95% CI)	P value
Age		0.98 (0.98–0.99)	0.001**
Male		1.15 (0.91–1.46)	0.243
Baseline ALT		1.02 (1.01–1.02)	< 0.001***
Metformin		1.17 (0.93–1.47)	0.181
TG & statin
	TG < 150 mg/dL, statin (−)	1
	TG < 150 mg/dL, statin (+)	0.86 (0.61–1.22)	0.390
	TG ≥ 150 mg/dL, statin (−)	1.62 (1.03–2.55)	0.038*
	TG ≥ 150 mg/dL, statin (+)	0.96 (0.67–1.38)	0.838
Class of ARB			0.002**
	Losartan	1
	Fimasartan	1.90 (1.39–2.59)	< 0.001***
	Candesartan	0.91 (0.66–1.26)	0.566
	Valsartan	1.19 (0.87–1.62)	0.280

ALT = alanine aminotransferase, ARB = angiotensin type II receptor blocker, HR = hazard ratio, CI = confidence interval, TG = triglyceride.

^*P < 0.05, ^**P < 0.01, ^***P < 0.001.