Figure 3.

Taxa significantly upregulated and downregulated in mice fed high-fat high-sugar diet alone and in combination with cranberry polyphenols. (A) Differential abundance analysis (DESeq2) revealed 79 amplicon sequence variants (ASVs) significantly modulated in mice fed high-fat high-sugar diet (HF) relative to lean mice fed chow diet (CT). (B) 32 ASVs were significantly modulated in mice fed HF + cranberry polyphenols (HF+CP) relative to HF mice. ASVs (p < 0.05, FDR-corrected) are represented by single data points (with some data points overlapping) within each genus grouped on the x-axis, and by color fitting to which taxonomic family the ASVs belong. Data are plotted as log2 fold change. n = 12 mice per group. ASVs to the right of the zero line are more abundant, and ASVs to the left of the zero line are less abundant.