TABLE 3.

Active efflux of GS-441524 (5 µM) in Caco-2, MDCK-MDR1 and MDCK-BCRP cell monolayers with the present and absence of Valspodar (MDR1 inhibitor) and Ko143 (BCRP inhibitor) (Data presented are the average of duplicate samples).

Cell Line	Inhibitor	Papp A to B (10–6 cm/s)	Papp B to A (10–6 cm/s)	Efflux Ratio
Caco-2	None	0.099	0.971	9.78
	1 µM Valspodar	0.16	0.79	4.93
	0.5 µM Ko143	0.229	0.267	1.16
MDCK-MDR1	None	0.158	0.521	3.29
	1 µM Valspodar	0.484	0.468	0.967
MDCK-BCRP	None	<0.197	0.385	>1.96
	0.5 µM Ko143	<0.198	<0.281	ND