TABLE 4.

Pharmacokinetic parameters of GS-441524 in mice, rats, monkeys, and dogs after single IV and PO administration.

Species	IV*		PO**
	CLp (mL/min/kg)	Vdss (L/kg)	Cmax (ng/mL)	Tmax (h)	AUC0-∞ (ng·h/mL)	t1/2 (h)	F (%)
Mouse***	26	2.4	582	1.5	2,540	3.9	39
Rat	25 ± 1.6	2.2 ± 0.3	193 ± 57	3.8 ± 2.4	2,170 ± 643	3.4 ± 0.2	33 ± 9.8
Monkey	9.5 ± 1.0	1.1 ± 0.04	59.4 ± 18.1	2.0 ± 0	734 ± 138	7.7 ± 1.4	8.3 ± 1.6
Dog	4.1 ± 0.70	0.92 ± 0.078	6,010 ± 1,400	0.28 ± 0.19	19,000 ± 5,200	4.1 ± 1.1	85 ± 17

*IV, dose: 5 mg/kg for mouse and rat; 2 mg/kg for dog and monkey.

**PO, dose: 10 mg/kg for mouse and rat; 5 mg/kg for dog and monkey.

***Mean concentrations at each time point were used in the pharmacokinetic parameter calculation.