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Pharmacokinetic parameters of GS-441524 in rats after single PO administration (Mean ± SD).
| Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUC0-∞ (ng·h/mL) | t1/2 (h) | F (%) |
|---|---|---|---|---|---|
| 10 | 193 ± 57 | 3.8 ± 2.4 | 2,170 ± 643 | 3.4 ± 0.2 | 33 ± 9.8 |
| 30 | 326 ± 77 | 3.8 ± 2.4 | 4,220 ± 746 | 3.4 ± 0.2 | 21 ± 3.8 |
| 100 | 825 ± 91 | 2.3 ± 1.3 | 9,560 ± 2,130 | 4.2 ± 1.8 | 15 ± 3.2 |
