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. 2022 Aug 14;8(8):e10220. doi: 10.1016/j.heliyon.2022.e10220

Table 1.

: Overview of different pharmacological activities of T. chebula.

Serial No Pharmacological activities Parts used Responsible compounds Extracts References
1 Anti-oxidant Fruits Ellagic acid, ascorbic acid, gallic acid Aqueous [31, 32, 33, 34, 35]
Leaf galls Phenolics and flavonoids Ethanolic [37]
Bark Phenolics and flavonoids Acetone [16]
2 Anti-lipid peroxidation Fruits Casuarinin, chebulanin, Chebulinic acid and 1,6-di-O-galloyl-β-D-glucose Aqueous [31]
3 Anti-inflammatory and anti-arthritic Fruits Chebulagic acid, chebulinic acid, corilagin, hydrolysable tannins Aqueous [48, 49, 50, 51, 52, 53]
4 Anti-diabetic and anti-hyperglycemic Fruits Chebulic acid, chebuloyl group Methanolic [62, 63, 64]
Fruits Tannin Alcoholic [66]
5 Hepatoprotective Fruits Chebulic acid; ellagitannins Aqueous [71, 72]
6 Anti-cancer Fruits Chebulinic acid, gallic acid, galloyl compounds Methanolic [81, 82, 83, 84, 85, 86, 87, 88]
7 Cardioprotective, hypolipidemic and hypocholesterolemic Leaves, fruits, Bark Chebulinic acid Methanolic [90, 91]
8 Gastroprotective and anti-ulcerogenic Fruits Chebulinic acid, polyphenols, flavonol aglycones Methanolic [97, 98, 99, 100, 101, 102, 103]
9 Neuroprotective Fruits Gallic acid, ellagic acid, tannic acid, chebulic acid Methanolic [108, 109, 110, 111, 112, 113]
10 Anti-convulsant Fruits Chebulinic acid, chebulagic acid Hydroalcoholic [118, 119]
11 Nephroprotective Fruits, leaves Polyphenols and tannins Chloroform, hydroalcoholic [61, 120]
12 Molluscicidal Fruit Tannic acid Ethanolic [126]
13 Radioprotective activity Fruit Polyphenols Aqueous [33]
14 Wound healing activity Leaves Hydrolysable tannins Methanolic [98, 136]
15 Cytoprotective activity Fruit Chebulic acid, gallic acid Ethanolic [142, 143]
16 Antiaging Leaf galls Polyphenols, flavonoids Cold water [11, 145]
17 Anti-androgenic Fruit Chebulinic acid Methanolic [147]
18 Antipsychiatry Fruit Chebulinic acid Ethanolic [149]
19 Antidiarrheal and Antimotility Fruit Gallic acid, 3,4,6-tri-O-galloyl- ​β-D-glucose, corilagin, and ellagic acid Aqueous [150]
20 Antibacterial Fruit Gallotannin and ellagic acid Methanolic [153]
Stem bark Triterpenoids and derivatives Methanolic [152]
21 Antiviral Fruit, bark Punicalagin, chebulagic acid, galloyl compounds Methanolic [12, 161, 162, 163]
22 Antifungal Galls, stem bark, seed Apigenin, phytol, stigmasterol Methanolic [172]
23 Antiparasitic Leaf, flower, seed Polyphenols Ethanolic [175]