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. 2022 Aug 16;10:931387. doi: 10.3389/fcell.2022.931387

FIGURE 1.

FIGURE 1

Prkn deletion does not lead to GBM development on the backdrop of Pten and Trp53 double knockout. (A). Schematic describing the generation of the PPP genetic model. The illustrations were made using BioRender. (B). The cohort sizes and brain tumor incidences tabulated for PPP, QPP, and PP models. (C). Kaplan-Meier survival curves (long rank test) for PPP, QPP, and PP mice treated with tamoxifen (at P7-P10) demonstrating a significantly (p < 0.0001) reduced brain tumor free survival rate for QPP and not for the PP and PPP. (D). Kaplan-Meier survival curves (long rank test) for PPP, and PP mice treated with tamoxifen (at P7-P8) demonstrating a significantly (p < 0.0001) reduced total survival rate for the PPP mice compared to the PP mice.

HHS Vulnerability Disclosure