Table 2.
showed the detailed analysis of the 4 human studies(randomerized controlled trials).
| S NO. | Author/Year/Study type | Number of PPI Users Non Users |
Mean age | Total number of implant | Location of implants | Dimension of implant (length × Diameter) |
Follow up | Implant survival | Implant failed | Study outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Wu et al., 2017 Retrosceptive cohort study |
799 Pts 58 PPIs users 741 non users |
18–93 years | 1773 implants 133 in PPIs users 1640 in non-users |
Maxilla & Mandible Anterior and posterior region |
12.1±.1 mm non users 12.1±.3 mm PPIs × 4.2±.5 mm non users( Mean ± SD) 4.1±.4 mm(Mean ± SD) |
Mean ± SD <12 months935 implants in non users 69 in PPIs users ≥12 months- 705 non users 64 implants in PPIs users |
124 in PPIs users 1587 in non users |
9 in PPIs users 53 in non users |
The study observed the increased risk of osseointegrated dental implant failure in PPIs users. |
| 2 | Chrcanovic et al., 2017 | 999 Pt 67 PPIs users 932 Non users |
≤30 years 31 ≤ 60 Years >60 years |
3559 implants 250 implants in PPIs users 3309 implants in non users |
Mandible anterior and posterior region | 6–10 mm, 10.5–14 mm, 15–20mm × 3-3.5omm, 3.70–4.10 mm, 4.20–5 mm |
94.8± 78.7 months |
220 in PPIs users 3161 in non users |
30 in PPIs users 148 in non users |
The study reported the association between PPIs administration and increased implant failure. |
| 3 | Altay et al., 2018 Retrospective study |
592 patients (316 female pt 276 male pt) 24(18 female and 6 males) PPIs Users 568 Non users |
18–84years | 1918 Implants 69 implants in PPIs Pt 1849 Implants in 568 non users |
Anterior region-506 implants Premolar region-603Implants Molar region 809 Implants (Mandible-957& Maxilla-961 Implants) |
Not mention | 29.02 ± 17.90 months for PPIs users 28.97 ± 17.59 months for non users | 45 implants in PPIs pt 1838 Implants in Non users |
24 in PPIs Pt 11 in Non users |
The study suggested association of PPIs with early dental implant failure. |
| 4 | Brendon et al., 2019 | 635 patients | 21 year or above | 201 implants in PPIs pt | Not mention | Not mention | 2–3 years | 190 implants in PPIs pt | 11 implants in PPIs pt | The study observed more crestal bone loss in dental implant patient having PPIs prescription history. |
| 1299 in Non users | 1270 implants in non users. | 24 in non users |