Table 3.
showed the detailed analysis of the 2 animal studies.
| S no | Author/Year | Total number of animals | Total number of implants placed | Age of animal | Study summary | Location of implant | Implant dimension | Inference |
|---|---|---|---|---|---|---|---|---|
| 1. | Subaie et al., 2016 | 24 Sprague Dawley Rat | 24 implants | 10 weeks | In 24 rats implants were placed in left tibia and defect was created in the right tibia. After surgery rat were on omeprazole (5 mg/kg) and others on saline. After euthanasia rat, percentage of new bone formation in the defect was assessed using microcomputed tomography and peri-implant bone mass or tissue volume and percentage of bone implant contact was observed by histomorphometry. | Tibia left | 1.5mm × 2.0 mm | Rats on PPIs shoe larger cortical bone defects. The systematic administration of these drugs impaired the bone healing. |
| 12 treated with Omeprazole | ||||||||
| 12 with saline | ||||||||
| 2. | Tekin et al., 2021 | 24 Sprague Dawley Rat | 48 implants | 2.5–3 months | In 24 sprague Dawley rats after surgical placement of Ti implant into the metaphyseal part of left and right tibia and randomly divided into three groups n = 8 omeprazole 5 mg/kg and n = 8 10 mg/kg and n = 8 control group. Total 48 implants were placed. After experiment animals from each group was scarified and study completed with 7 rats in each group. Blood samples were collected for biochecimal analysis and implant and surrounding tissue were used for biomechanical reserve torque analysis. | Left and right Tibia | 4mm × 2.5 mm | PPIs have no biomechanical or biomchecimal effect on dental implant osseointegration. |
| N = 8 controls | 32 in PPIs treated | |||||||
| N = 8 on 5 mg/kg of omeprazole | 16 in non treared | |||||||
| N = 8 on 10 mg/kg of omprazole |