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. 2022 Aug 16;13:955091. doi: 10.3389/fimmu.2022.955091

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Copyright © 2022 Zhao, Song, Wu, Yang, Shi, Cui, Ren and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The knockdown of OTUD6B in lung cancer cells inhibits tumor self-renewal. (A) Immunoblot (IB) of OTUD6B expression in six randomly selected lung cancer samples (T) and their paired Normal (N) samples. n = 6 independent experiments. (B) Western blot validation of OTUD6B knockdown using siRNA in Pc9 and A549 cells. (C) Transwell migration assays in OTUD6B-knockdown Pc9 and A549 cells following transfection with the indicated siRNAs, typical images in the upper panels and invasive cell numbers in the lower panel. Scale bars, 70 μm. (D) OTUD6B knockdown inhibits Pc9 and A549 cell migration distance as seen in wound healing assays. (E) Cell proliferation detection of lung cancer cells was measured by clone formation. (F) Xenograft tumor models show that tumors grown from OTUD6B knockdown cells were smaller compared with those grown from control cells. (**p < 0.01; ****p < 0.0001).