Table 2.
Interaction of Arg72Pro and MDM2 SNP309 on the HPV infection and oncogenic risk status.
| HPV infection |
p | HPV genotypes |
p | |||
|---|---|---|---|---|---|---|
| HPV-positive n (%) |
HPV-negative n (%) |
High-riska n (%) |
Low-riska n (%) |
|||
| P53 genotypes | ||||||
| Arg72Arg | 31 (45.6) | 8 (25) | 10 (52.6) | 18 (47.4) | ||
| Arg72Pro | 25 (36.8) | 18 (56.2) | 0.11 | 6 (31.6) | 14 (36.8) | 0.91 |
| Pro72Pro | 12 (17.6) | 6 (18.8) | 3 (15.8) | 6 (15.8) | ||
| P53 alleles | ||||||
| Arginine carriers | 56 (84.2) | 26 (81.2) | 0.89 | 16 (84.2) | 32 (84.2) | 1.00 |
| Proline carriers | 37 (554.4) | 24 (75) | 0.04 | 9 (47.4) | 20 (52.6) | 0.70 |
| MDM2 genotypes | ||||||
| TT | 23 (33.8) | 16 (50) | 8 (42.1) | 9 (23.7) | ||
| TG | 34 (50) | 11 (34.4) | 0.26 | 6 (31.6) | 25 (65.8) | 0.04 |
| GG | 11 (16.2) | 5 (16.2) | 5 (26.3) | 4 (10.5) | ||
| MDM2 alleles | ||||||
| Thymine carriers | 57 (83.8) | 27 (84.4) | 0.94 | 14 (73.7) | 34 (89.5) | 0.12 |
| Guanine carriers | 45 (66.2) | 16 (50) | 0.12 | 11 (57.9) | 29 (76.3) | 0.15 |
a
Total of 57 samples.