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. 2022 Aug 29;182(10):1052–1060. doi: 10.1001/jamainternmed.2022.3697

Table 3. Causes of the 117 Deaths in the Cohort .

Causes of deatha Deaths, No. (%)
Heart disease 17 (14.5)
Cancer 17 (14.5)
Liver and intrahepatic bile ducts 4 (3.4)
Trachea, bronchus, and lung 3 (2.6)
Prostate 2 (1.7)
Colon, rectum, and anus 2 (1.7)
Bladder 1 (1.0)
Stomach 1 (1.0)
Non-Hodgkin lymphoma 1 (1.0)
Multiple myeloma and myeloproliferative disorders 1 (1.0)
Corpus uteri and uterus 1 (1.0)
All other and unspecified malignant neoplasms (leiomyosarcoma) 1 (1.0)
Drug overdose 14 (12.0)
Polysubstanceb 6 (5.1)
Cocaine 3 (2.6)
Amphetamines 3 (2.6)
Opioids 2 (1.7)
Chronic lower respiratory diseases 11 (9.4)
Chronic liver disease and cirrhosis 8 (6.8)
Cerebrovascular disease 7 (6.0)
Accidents 6 (5.1)
Pneumonia 5 (4.3)
Nephritis, nephrotic syndrome, and nephrosis 4 (3.4)
COVID-19 3 (2.6)
Diabetes 3 (2.6)
HIV 3 (2.6)
Homicide 2 (1.7)
Other digestive diseases (gastrointestinal hemorrhage) 2 (1.7)
All other diseases (amyloidosis) 1 (1.0)
Psychoactive substance use disorder 1 (1.0)
Missing 13 (11.1)
a

Causes of death based on the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision underlying cause of death codes.

b

Of the 6 polysubstance-related deaths, 1 was attributed to alcohol and cocaine and 1 to cocaine and methamphetamine; the causes of the other 4 deaths were not further specified.