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. 2022 Jun 30;107(9):2037–2050. doi: 10.3324/haematol.2022.280953

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Copyright© 2022 Ferrata Storti Foundation

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Figure 4. — Management of IgM-related neuropathies. *Nerve biopsy after consultation with an expert neurologist, in selected cases only. CNS: central nervous system; HIV: human immunodeficiency virus; CIDP: chronic inflammatory demyelinating polyneuropathy; MAG: myelin-associated glycoprotein; Ab: antibody; NCS/EMG: nerve conduction studies/electromyography; MRI: magnetic resonance imaging; CSF: cerebrospinal fluid; CANOMAD: chronic ataxic neuropathy, ophthalmoplegia, IgM M-protein, cold agglutinins and disialosyl ganglioside antibodies; POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities; BR: bendamustine plus rituximab; DRC: dexamethasone, rituximab, cyclophosphamide.