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. 2022 Jul 30;11(15):2353. doi: 10.3390/cells11152353

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Respiratory substrates affinity in OHSU-974-FAcorr and OHSU-974-S91. (A) Graphical representation of the inhibitors targets used to evaluate the respiratory substrates’ affinity of OxPhos metabolism. BPTES is a glutaminase inhibitor; Etomoxir prevents the transport of fatty acids to the mitochondrion, inhibiting beta-oxidation; and UK5099 is Pyruvate Dehydrogenase (PDH) inhibitor. (B) The extent of OCR for glucose (inhibited by UK5099, Bordeaux), glutamine (inhibited by BPTES, Blue), and fatty acids (inhibited by Etomoxir, green). (C) The extent of ATP synthesis through F_oF₁ ATP-synthase for glucose (inhibited by UK5099, Bordeaux), glutamine (inhibited by BPTES, Blue), and fatty acids (inhibited by Etomoxir, green). Data are reported as mean ± SD, and each graph is representative of at least 3 independent experiments. Statistical significance was tested with two-way ANOVA. * and ** represent a p < 0.05 and 0.01, respectively, between OHSU-974-S91 cells and the OHSU-974-FAcorr cells used as control.