. 2017 Oct 13;21(6):665–669. doi: 10.1016/j.bjid.2017.09.002

Table 1.

Comparison of outcomes among SOFA and SIRS criteria defining sepsis in 1487 critical care patients with infection at ICU admission.

Outcomes	Group 1 SIRS+	Group 2 SIRS+	Group 3 SIRS−	Group 3 SIRS−	Kruskal–Wallis or Pearson Chi²	Comparison group	Post hoc p-value
	SOFA+	SOFA−	SOFA+	SOFA−
	(n = 867)	(n = 153)	(n = 308)	(n = 159)
ICU mortality, % (n)	26.8 (233)	16.3 (25)	14.2 (44)	5.6 (9)	Chi² 51.1	1 vs. 2	0.03
					p < 0.001	1 vs. 3	<0.001
						1 vs. 4	<0.001
						2 vs. 3	0.44
						2 vs. 4	0.01
						3 vs. 4	0.03

Need for MV, % (n)	68.5 (594)	45.7 (70)	54.2 (167)	20.1 (32)	Chi² 144.8	1 vs. 2	<0.001
					p < 0.001	1 vs. 3	<0.001
						1 vs. 4	<0.001
						2 vs. 3	0.18
						2 vs. 4	<0.001
						3 vs. 4	<0.001

Length of MV, days, median (IQR)	6 (3, 13)	6 (2, 11)	4 (1, 10)	2 (1, 7)	Chi² 19.3	1 vs. 2	0.90
					p < 0.001	1 vs. 3	0.004
						1 vs. 4	0.002
						2 vs. 3	0.22
						2 vs. 4	0.10
						3 vs. 4	0.32

Length of ICU stay, days, median (IQR)	10 (5, 19)	7 (4, 15)	7 (4, 15)	4 (2, 9)	Chi² 83.5	1 vs. 2	<0.001
					p < 0.001	1 vs. 3	<0.001
						1 vs. 4	<0.001
						2 vs. 3	0.99
						2 vs. 4	<0.001
						3 vs. 4	<0.001

Length of hospitalization, days, median (IQR)	18 (10, 34)	14 (8, 29)	16 (9, 32)	11 (7, 22)	Chi² 29.9	1 vs. 2	0.15
					p < 0.001	1 vs. 3	0.62
						1 vs. 4	<0.001
						2 vs. 3	0.68
						2 vs. 4	0.42
						3 vs. 4	<0.001

ICU, intensive care unit; IQR, interquartile range; MV, mechanical ventilation; SIRS, systemic inflammatory response syndrome; SOFA, sequential organ failure assessment.

Note: SOFA+, patients with SOFA variation ≥2 over their baseline clinical score. SIRS+, patients with at least 2 of the following signs of SIRS: temperature > 38 °C or <36° C, heart rate > 90 beats per minute, respiratory rate > 20 breaths per minute or PaCO₂ < 32 mmHg, abnormal white blood cell count (>12,000/μL or <4000/μL or >10% immature forms).