Table 1.
Specific antimicrobial protocol for outpatient parenteral antimicrobial therapy.
| Antimicrobial | Dosage regimen for normal renal function | Possible colateral effects | Monitoring | Special observations |
|---|---|---|---|---|
| Teicoplanin | 400–600 mg qd | - Skin rash - Renal impairment - Liver impairment - Bone marrow impairment (mainly leucopenia) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities |
| Ertapenem | 1 g qd | - Liver impairment - Convulsions - Mental confusion (specially in elderly) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities |
| Ceftriaxone | 2 g qd | - Liver impairment - Bone marrow impairment (mainly leucopenia) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities |
| Vancomycin | 1 g q12 hours | - Skin rash - Renal impairment - Liver impairment - Bone marrow impairment (mainly leucopenia) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a week | - Contact hospital (IOT) team if abnormalities - Slow infusion |
| Meropenem | 2 g q12 hours | - Liver impairment - Convulsions - Mental confusion (specially in elderly) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities |
| Ceftazidime | 2 g q12 hours | - Liver impairment - Bone marrow impairment (mainly leucopenia) |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities |
| Tigecycline | 50 mg q12 hours | - Liver impairment - Cholestasis - Nausea/vomiting |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a month | - Contact hospital (IOT) team if abnormalities - Nausea may demand antiemetic infusion before antibiotic |
| Linezolid | 600 mg q12 hours | - Bone marrow impairment (mainly anemia) - Optic nerve impairment |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram once a week | - Contact hospital (IOT) team if abnormalities |
| Colistin | 150 mg q12 hours | - Renal impairment - Peripheral neuropathy |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram twice a week | - Contact hospital (IOT) team if abnormalities |
| Amicacin | 1 g qd | - Renal impairment - Hearing impairment |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram twice a week | - Contact hospital (IOT) team if abnormalities |
| Gentamycin | 240 mg qd | - Renal impairment - Hearing impairment |
Urea, creatinine, AST, ALT, alkaline phosphatase, gamma GT and hemogram twice a week | - Contact hospital (IOT) team if abnormalities |