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. 2017 Jul 14;21(6):648–655. doi: 10.1016/j.bjid.2017.06.006

Table 4.

Recommendations and instructions for antimicrobial use in OPAT in Brazil.

Antimicrobial Dose and posology for normal renal and hepatic functions Reconstitution Dilution Duration of infusion
Amikacin 15 mg/kg once a day Not required 100–200 mL of 0.9% SS, 5% GS or Ringer's lactate solution 30–60 min
×


Gentamicin 5 mg/kg once a day Not required 50–200 mL of 5% GS 30–120 min



Cefepime 2 g twice a day 10 mL of sterile distilled water 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution 30 min



Ceftaroline 600 mg twice a day 20 mL of sterile distilled water 50–250 mL of 0.9% SS, 5% GS or Ringer's lactate solution 30 min



Ceftazidime 2 g twice a day 5–10 mL of sterile distilled water 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution 30–60 min



Ceftriaxone 2 g once a day 10 mL of sterile distilled water 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution 15–30 min



Ertapenem 1 g once a day 10 mL of sterile distilled water 50 mL of 0.9% SS 30 min



Meropenem 2 g twice a day 20 mL of sterile distilled water 250 mL of 0.9% SS or 5% GS 60 min



Vancomycin 15 mg/kg twice a day 10 mL of sterile distilled water 200 mL of 0.9% SS or 5% GS 60 min



Teicoplanin 6 mg/kg once a day 10 mL of sterile distilled water 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution 60 min



Daptomycin 4–6 mg/kg once a day 10 mL of 0.9% SS 50 mL of 0.9% SS 30 min



Linezolid 600 mg twice a day Not required 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution 30–120 min



Tigecycline 50 mg twice a day Not required 50 mL of 5% GS 30–60 min



Anidulafungin 100 mg once a day 30 mL of its own diluent 100 mL of 0.9% SS or 5% GS 90 min



Caspofungin 50 mg once a day 10 mL of sterile distilled water 100 mL of 0.9% SS 60 min



Micafungin 100 mg once a day 5 mL of 0.9% SS 50 mL of 0.9% SS or 5% GS 60 min



Voriconazole 3–4 mg/kg twice a day 19 mL of sterile distilled water 200–250 mL of 0.9% SS, 5% GS or Ringer's lactate solution 60–120v



Amphotericin B (lipid complex) 5 mg/kg once a day 20 mL of sterile distilled water 200–500 mL of 5% GS 120 min



Amphotericin B (liposomal) 3–5 mg/kg once a day 10 mL of sterile distilled water 200–500 mL of 5% GS 120 min

0.9% SS, 0.9% saline solution; 5% GS, 5% glucose solution.

OPAT, outpatient parenteral antimicrobial therapy.