Table 4.
Recommendations and instructions for antimicrobial use in OPAT in Brazil.
| Antimicrobial | Dose and posology for normal renal and hepatic functions | Reconstitution | Dilution | Duration of infusion |
|---|---|---|---|---|
| Amikacin | 15 mg/kg once a day | Not required | 100–200 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 30–60 min |
| × | ||||
| Gentamicin | 5 mg/kg once a day | Not required | 50–200 mL of 5% GS | 30–120 min |
| Cefepime | 2 g twice a day | 10 mL of sterile distilled water | 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 30 min |
| Ceftaroline | 600 mg twice a day | 20 mL of sterile distilled water | 50–250 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 30 min |
| Ceftazidime | 2 g twice a day | 5–10 mL of sterile distilled water | 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 30–60 min |
| Ceftriaxone | 2 g once a day | 10 mL of sterile distilled water | 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 15–30 min |
| Ertapenem | 1 g once a day | 10 mL of sterile distilled water | 50 mL of 0.9% SS | 30 min |
| Meropenem | 2 g twice a day | 20 mL of sterile distilled water | 250 mL of 0.9% SS or 5% GS | 60 min |
| Vancomycin | 15 mg/kg twice a day | 10 mL of sterile distilled water | 200 mL of 0.9% SS or 5% GS | 60 min |
| Teicoplanin | 6 mg/kg once a day | 10 mL of sterile distilled water | 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 60 min |
| Daptomycin | 4–6 mg/kg once a day | 10 mL of 0.9% SS | 50 mL of 0.9% SS | 30 min |
| Linezolid | 600 mg twice a day | Not required | 50–100 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 30–120 min |
| Tigecycline | 50 mg twice a day | Not required | 50 mL of 5% GS | 30–60 min |
| Anidulafungin | 100 mg once a day | 30 mL of its own diluent | 100 mL of 0.9% SS or 5% GS | 90 min |
| Caspofungin | 50 mg once a day | 10 mL of sterile distilled water | 100 mL of 0.9% SS | 60 min |
| Micafungin | 100 mg once a day | 5 mL of 0.9% SS | 50 mL of 0.9% SS or 5% GS | 60 min |
| Voriconazole | 3–4 mg/kg twice a day | 19 mL of sterile distilled water | 200–250 mL of 0.9% SS, 5% GS or Ringer's lactate solution | 60–120v |
| Amphotericin B (lipid complex) | 5 mg/kg once a day | 20 mL of sterile distilled water | 200–500 mL of 5% GS | 120 min |
| Amphotericin B (liposomal) | 3–5 mg/kg once a day | 10 mL of sterile distilled water | 200–500 mL of 5% GS | 120 min |
0.9% SS, 0.9% saline solution; 5% GS, 5% glucose solution.
OPAT, outpatient parenteral antimicrobial therapy.