Table 1.
Studies of repositioning non-antibiotic drugs with antibiotic effect.
| Drug | Original indication | New indication | Reference | |
|---|---|---|---|---|
| AAS | Non-steroidal Anti-inflammatory | MRSA | Chan et al., 201710 | |
| Amitriptiline | Antidepressant |
Staphylococcus spp. Enterococcus faecalis Micrococcus luteus Bacillus spp. Shigella spp. Salmonella spp. Vibrio cholerae Vibrio parahaemolyticus Escherichia coli Klebsiella pneumonia Pseudomonas spp. Proteus spp. Citrobacter spp. Providencia spp. Enterobacter cloacae Hafnia spp. Lactobacillus sporogenes Micrococcus flavus Vibrio cholerae |
Mandal et al., 201011 Muthukumar and Janakiraman, 201422 |
|
| Auranofin | Rheumatoidarthritis | MRSA | Harbut et al., 201523 | |
| Chlorpromazine | Anti-psychotic |
Corynebacterium urealyticum Escherichia coli Klebsiella pneumoniae Citrobacter freundii Morganella morganii Acinetobacter baumannii Haemophilus influenzae Moraxella catarrhalis Campylobacter jejuni Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus agalactiae Enterococcus faecalis Clostridium perfringens Clostridium difficile Bacreroides fragilis Prevotella spp. Brucella spp. |
Munoz-Bellido, Munoz-Criado and García-Rodríguez, 199612 Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 |
|
| Clofazime | Tuberculosis | Mycobacterium leprae | Naylorand Schonfeld, 201424 | |
| Clomipramine | Antidepressant |
Serratia marcescens Morganella morganii Acinetobacter baumannii Haemophilus influenza Campylobacter jejuni Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus agalactiae Enterococcus faecalis Clostridium perfringens Clostridium difficile Bacteroides fragilis Prevotella spp. Brucella spp. |
Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 | |
| Disulfiram | Alcoholism | MRSA Pseudomonas aeruginosa |
Phillips et al., 199125 Velasco-García et al., 200626 |
|
| Ebselen | Neuroprotector | MRSA VRSA Streptococcus spp. Enterococcus spp. |
Thangamani, Younis e Seleem 2015[6], [7] | |
| Escitalopram | Antidepressant |
Klebsiella pneumoniae Proteus mirabilis Enterobactor cloacae Staphylococcus aureus Pseudomonas aeruginosa |
Akilandeswari, Ruckmani and Ranjith, 201327 | |
| Fluoxetine | Antidepressant |
Corynebacterium urealyticum Haemophilus influenzae Moraxella catarrhales Campylobacter jejuni |
Munoz-Bellido, Munoz-Criado and García-Rodríguez, 199612 Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 |
|
| Ibuprofen | Non-steroidalAnti-inflammatory | MRSA | Chan et al., 201710 | |
| Iproniazid | Antidepressant | Mycobacterium tuberculosis | López-Muñoz and Alamo, 200928 | |
| Loperamide | Diarrhoea | Salmonella enterica | Ejim et al., 201116 | |
| Sertraline | Antidepressant |
Corynebacterium urealyticum Escherichia coli Klebsiella pneumoniae Enterococcus cloacae Citrobacter freundii Serratia marcescens Proteus mirabilis Proteus vulgaris Morganella morganii Acinetobacter baumannii Haemophilus influenzae Moraxella catarrhalis Campylobacter jejuni Staphylococcus aureus Staphylococcus epidermidis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus agalactiae Enterococcus faecalis Clostridium perfringens Clostridium difficile Bacteroides fragilis Prevotella spp. Brucella spp. Staphylococcus spp. Micrococcus luteus Bacillus subtilis Shigella spp. Salmonella spp. Vibrio cholerae Vibrio parahaemolyticus Pseudomonas aeruginosa Providencia spp. Lactobacillus sporogenes |
Munoz-Bellido, Munoz-Criado and García-Rodríguez, 199612 Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 Samanta et al., 201229 |
|
| Paroxetine | Antidepressant |
Corynebacterium urealyticum Haemophilus influenzae Moraxella catarrhales Campylobacter jejuni |
Munoz-Bellido, Munoz-Criado and García-Rodríguez, 199612 Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 |
|
| Risperidone | Anti-psychotic | Corynebacterium urealyticum | Munoz-Bellido, Munoz-Criado and García-Rodríguez, 199612 Munoz-Bellido, Munoz-Criado and García-Rodríguez, 200013 |
|
| Simvastatin and Atorvastatin | Cardiovascular diseases |
Staphylococcus epidermidis Staphylococcus aureus Salmonella spp. Pseudomonas aeruginosa Micrococcus luteus Klebsiella pneumoniae Escherichia coli Enterococcus faecalis Enterobacter hormaechei Bacillus cereus Staphylococcus spp. Staphylococcus coagulase negative MRSA |
Rampelotto et al., 2018 in press14 Graziano et al., 201530 |
|
| Thalidomide | Anti-nausea | Mycobacterium leprae | Paravar and Lee, 200831 | |
MRSA, methicillin-resistant Staphylococcus aureus; VRSA, vancomycin-resistant Staphylococcus aureus; AAS, acetylsalicylic acid.