Table 1.
Demographic and HIV-related characteristics of the global cohort and comparative analysis regarding the presence of mildly-reduced eGFR (glomerular filtration rate, estimated by CKD-EPI creatinine equation, between 60 and 89 mL/min/1.73 m2).
| Variable | Global cohort | Normal eGFR | Mildly-reduced eGFR | p-value |
|---|---|---|---|---|
| Number of patients | 4337 | 3254 | 1083 | – |
| Age, yearsa | 44 (14) | 43 (14) | 50 (13) | <0.001 |
| Female gender, n (%) | 819 (18.9) | 580 (17.8) | 239 (22.1) | 0.002 |
| Black race, n (%) (n = 2729) | 55 (2.0) | 40 (1.8) | 15 (2.5) | 0.281 |
| Body mass index, kg/m2a(n = 1373) | 22.9 (3.5) | 22.8 (3.4) | 23.2 (3.3) | 0.040 |
| Hypertension, n (%) | 530 (12.2) | 296 (9.1) | 234 (21.6) | <0.001 |
| Diabetes mellitus, n (%) | 199 (4.6) | 120 (3.7) | 79 (7.3) | <0.001 |
| Dyslipidemia, n (%) | 528 (12.2) | 302 (9.3) | 226 (20.9) | <0.001 |
| Cardiovascular events, n (%) | 168 (3.9) | 97 (3.0) | 71 (6.6) | <0.001 |
| HBV coinfection, n (%) | 145 (3.3) | 100 (3.1) | 45 (4.2) | 0.325 |
| HCV coinfection, n (%) (n = 4329) | 951 (22.0) | 708 (21.8) | 243 (22.5) | 0.639 |
| Duration of HIV infection, yearsa(n = 4313) | 10.7 (13.9) | 9.6 (13.7) | 14.1 (12.6) | <0.001 |
| Route of HIV acquisition, n (%) | ||||
| Heterosexual | 1116 (25.7) | 788 (24.2) | 328 (30.3) | <0.001 |
| Homosexual | 2590 (59.7) | 1997 (61.4) | 593 (54.8) | <0.001 |
| Injecting-drug abuse | 602 (13.9) | 445 (13.7) | 157 (14.5) | 0.681 |
| Another route | 48 (1.1) | 37 (1.1) | 11 (1.0) | 0.778 |
| Unknown | 228 (5.3) | 175 (5.4) | 53 (4.9) | 0.536 |
| Prior AIDS events, n (%) | 837 (19.3) | 578 (17.8) | 259 (23.9) | <0.001 |
| HIV suppression, n (%) | ||||
| On treatment | 3840 (88.5) | 2825 (86.8) | 1015 (93.7) | |
| Without treatment | 29 (0.7) | 23 (0.7) | 6 (0.6) | <0.001 |
| No suppression | 468 (10.8) | 406 (12.5) | 62 (5.7) | |
| Viral load, copies/mLa | ||||
| First | 23,622 (116,567) | 22,300 (105,867) | 28,670 (160,438) | 0.018 |
| Higher | 67,951 (233,350) | 62,934 (209,910) | 88,730 (286,825) | <0.001 |
| CD4 cell count, cells/mm3 | ||||
| Lower (nadir) | 252 (237) | 264 (237) | 219 (240) | <0.001 |
| Current | 633 (375) | 634 (372) | 626 (394) | 0.991 |
a
Results expressed as median and interquartile range (IQR).
HCV, hepatitis C virus; HBV, hepatitis B virus. Significant p < 0.05.