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. 2022 Aug 30;21:171. doi: 10.1186/s12943-022-01642-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — S6K1 amplification correlates with poor outcome in patients with breast cancer from public database. A The incidence of S6K1 genetic alteration in different cancer types from 10,967 samples, obtained by summarizing the data of TCGA PanCancer Atlas Studies on cBioPortal. B The mRNA level of S6K1 gene in TCGA patients with various cancers are reported as median FPKM (Fragment Per Kilobase of exon per Million reads), downloaded from the Human Protein Atlas. Data are represented as the mean ± SEM. P value was calculated by Kruskal-Wallis test. ****, P < 0.0001. C The S6K1 locus was substantially amplified in breast cancer samples from oestrogen receptor (ER) positive subtypes based on cBioPortal. D The correlations between the mRNA levels of S6K1 and cell cycle-related genes in BRCA cohort, using data from the GEPIA. E Kaplan-Meier Plotter showing the relapse free survival of patients with breast cancer according to S6K1 mRNA levels