Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 30;21:171. doi: 10.1186/s12943-022-01642-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Elevated expression of S6K1 is related to palbociclib resistance in the validation patient cohort. A The expression of S6K1 in patients with breast cancer was detected by immunohistochemistry (IHC). High S6K1 expression (positive score 6-8) was observed in 15/104 (14%) of patients. B Kaplan–Meier curves for PFS in the validation patient cohort who had received palbociclib treatment according to S6K1 expression. P value was calculated by log-rank test. C Copy number variation profiles for the S6K1 loci using droplet digital PCR (ddPCR). D Representative images showing multiplex immunofluorescence (multi-IF) stanning of tissue samples from patients with high or low S6K1 expression. E The expression of S6K1 had a high correlation with cyclin E1 and p-Rb based on the results of multi-IF in the patient with high S6K1 expression. F The proportion of p-Rb + S6K1+ cells and cyclin E1 + S6K1+ cells in patients with high or low S6K1 expression. Data are represented as the mean ± SD. P value was calculated by Mann-Whitney test. ****, P < 0.0001