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. 2022 Aug 29;22:933. doi: 10.1186/s12885-022-10032-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Deficiency of Notch signaling leads to increased chemokine expression in CRC tumor microenvironment. A RT-PCR result showing decreased NOTCH1 expression in MC38 cell line stably transected with shNOTCH1 (***p < 0.001). B WB result showing decreased NOTCH1 protein level in MC38 cell line stably transected with shNOTCH1. Full-length blot is presented in the supplementary material. C Gene sets enriched in the control and knock-down groups. D The expressions of Cx3cl1, Cxcl1 and Ccl9 in the control and knock-down groups (**p < 0.01, ***p < 0.001). E The expression levels of CX3CL1 and CXCL1 in the WT and mutation patients of TCGA (ns, not significant, ***p < 0.001). F The infiltration scores of different immune cells in the WT and mutation patients of CRC in TCGA (*p < 0.05, ***p < 0.001)