TABLE 3.

Quartiles and continuous hazard ratios for risk of HCC by HFC‐PRS and East Asian NAFLD‐PRS in the SCHS

Weighted score quartile	Persons	Person‐years	Cases	HR a (95% CI)	p a	HR b (95% CI)	p b	HR c (95% CI)	p c
HFC‐PRS (n = 24,333, 208 HCC Cases)
First quartile (<0.128)	4730	88,859	24	1.00		1.00		1.00
Second quartile (0.128 to <0.331)	6337	119,466	50	1.59 (0.98, 2.58)	0.063	1.61 (0.99, 2.61)	0.056	1.62 (1.00, 2.64)	0.051
Third quartile (0.331 to <0.459)	7157	135,516	60	1.64 (1.02, 2.63)	0.041	1.60 (1.00, 2.58)	0.050	1.62 (1.01, 2.60)	0.046
Fourth quartile (≥0.459)	6109	114,865	74	2.39 (1.51, 3.78)	0.0002	2.31 (1.46, 3.66)	0.0004	2.35 (1.48, 3.73)	0.0003
p trend				0.0002		0.0004		0.0003
Continuous, HR for 1‐SD increase (SD = 0.22)				1.38 (1.21, 1.57)	<0.001	1.37 (1.20, 1.55)	<0.001	1.37 (1.20, 1.56)	<0.001
East Asian NAFLD‐PRS (n = 24,294, 206 HCC cases)
First quartile (<0.615)	4594	85,933	29	1.00		1.00		1.00
Second quartile (0.615 to <0.937)	6121	115,712	43	1.13 (0.71, 1.82)	0.601	1.14 (0.71, 1.82)	0.598	1.15 (0.72, 1.84)	0.569
Third quartile (0.937 to <1.259)	7310	137,843	63	1.37 (0.88, 2.13)	0.161	1.34 (0.86, 2.09)	0.189	1.35 (0.87, 2.10)	0.178
Fourth quartile (≥1.259)	6269	118,489	71	1.77 (1.15, 2.73)	0.009	1.68 (1.09, 2.60)	0.018	1.70 (1.10, 2.62)	0.017
p trend				0.003		0.008		0.007
Continuous, HR for 1‐SD increase (SD = 0.52)				1.26 (1.10, 1.44)	0.0006	1.24 (1.09, 1.42)	0.002	1.24 (1.09, 1.42)	0.001

Abbreviation: HR, hazard ratio.

^a Adjusted for age and sex only.

^b Adjusted for age, sex, dialect, BMI, education, smoking status, alcohol intake, year of enrollment, and diabetes status.

^c Adjusted for all covariates in model b with additional adjustment for principal components 1–3.