TABLE 4.

Causal estimates of NAFLD on HCC by multiple MR approaches using gene variants included in the East Asian NAFLD‐PRS as instruments

Method	Intercept a	Beta	HR (95% CI)	p
IVW	—	0.457	1.58 (1.22, 2.04)	<0.001
Simple median	—	0.462	1.59 (1.12, 2.25)	0.01
Weighted median	—	0.457	1.58 (1.19, 2.1)	0.002
Contamination mixture method	—	0.46	1.58 (1.22, 2.03)	<0.001
Maximum‐likelihood method	—	0.457	1.58 (1.21, 2.06)	0.001
MR‐Egger	0.006	0.445	1.56 (0.69, 3.51)	0.281
Robust MR‐Egger	0.006	0.445	1.56 (1.24, 1.97)	<0.001

^a p value for intercept terms: MR‐Egger = 0.976; robust MR‐Egger = 0.938.