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. 2022 May 16;6(9):2273–2285. doi: 10.1002/hep4.1993

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© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Changes in intrahepatic fat content and liver tests. (A) Magnetic resonance imaging proton density fat fraction (MRI‐PDFF) changes compared between baseline and tofogliflozin monotherapy, pioglitazone monotherapy, and combination of tofogliflozin and pioglitazone. (B) Change in MRI‐PDFF after 24 weeks and 48 weeks of monotherapy and combination therapy, listed by initial monotherapy. (C) Alanine transaminase (ALT) level changes compared between baseline and tofogliflozin monotherapy, pioglitazone monotherapy, and combination of tofogliflozin and pioglitazone. (D) Change in ALT levels after 12 weeks (monotherapy), 24 weeks (monotherapy), 36 weeks (combination therapy), and 48 weeks (combination therapy), listed by initial monotherapy