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. 2022 Jul 12;13(4):e01687-22. doi: 10.1128/mbio.01687-22

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Copyright © 2022 Sukumaran et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Global proteome response to shifting the macrophage microbiome. (A) Total number of proteins identified for the host (2,292), C. neoformans (128), and K. pneumoniae (167) via proteomics profiling; (B) principal-component analysis of the experiment; (C) heat map of hierarchical clustering by Euclidean distance for the detected proteins across all samples; (D) CFU counts for C. neoformans and K. pneumoniae following infection experiments. Statistical analysis using Student's t test: *, P < 0.05; **, P < 0.001; ***, P < 0.0001. The experiment was performed in biological quadruplicate. I, immediate; E, established.