FIG 4.

Fungal proteome signatures upon invasion, adaptation, and disruption. (A) Distribution of GOBP terms for identified fungal proteins. (B) Volcano plot for comparison of fungal proteins between immediate and established C. neoformans infection. The number of significantly different proteins identified under each condition (Venn diagram) and distribution of GOBP terms between fungal proteins with significant increases or decreases in abundance upon infection are shown. (C) Volcano plot for comparison of fungal proteins between established C. neoformans infection and coinfection (established C. neoformans plus immediate K. pneumoniae infection). The number of proteins identified under each condition is shown (Venn diagram). (D) Volcano plot for comparison of fungal proteins established C. neoformans infection and established coinfection (established C. neoformans plus established K. pneumoniae infection). The number of significantly different proteins identified under each condition (Venn diagram) and distribution of GOBP terms between fungal proteins with significant increases or decreases in abundance upon infection are shown. Volcano plots: Student’s t test, P < 0.05; FDR = 0.05; S₀ = 1. Orange denotes C. neoformans proteins. The experiment was performed in biological quadruplicate.