TABLE 1.
Resistance of different E. faecalis strains to antimicrobials
| Antibiotic | OG1 MIC (ug/mL)a |
CK221 (erythromycin sensitive V583) MIC (ug/mL)a |
||||||
|---|---|---|---|---|---|---|---|---|
| Wild-typeb | ΔcroR | Δpbp4(5) | pbp4(5) ATAA mutant | Wild-typec | ΔcroR | Δpbp4(5) | pbp4(5) ATAA mutant | |
| Cefuroxime (2nd gen) | 128 | 8 | ≤1 | 16 | 512 | ≤2 | ≤2 | 16 |
| Ceftriaxone (3rd gen) | 32 | 4 | ≤2 | 16 | 512 | ≤4 | ≤4 | 16 |
| Cefepime (4th gen) | 32 | 16 | 4 | 16 | 32 | 4 | 2 | 16 |
| Ampicillin | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.125 | 0.5 | 0.5 |
| Vancomycin | 2 | 0.5 | 2 | 2 | 16 | ≤4 | 16 | 16 |
a
Median MIC determined from ≥2 independent replicates.
b
Derivatives of E. faecalis OG1 were ΔcroR, SB23; Δpbp4(5), JL339; pbp4(5) ATAA mutant (4 bp substitutions in pbp4(5) promoter), ST4.
c
Derivatives of E. faecalis CK221 were ΔcroR, SB45; Δpbp4(5), JL640; pbp4(5) ATAA mutant (4 bp substitutions in pbp4(5) promoter), ST8.