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. 2022 Jun 22;7(4):e00353-22. doi: 10.1128/msystems.00353-22

FIG 4.

FIG 4

Representative metabolites perturbed by IAV infection in serum and lung tissue. n = 16 infected mice and n = 10 uninfected mice. (A to C) Statistically significant metabolites altered by infection in serum (Wilcoxon FDR-corrected P value, <0.001). (A) Methionine (m/z 150.058, RT 0.323 min). (B) Oleoylcarnitine (m/z 426.357, RT 2.982 min). (C) Palmitoylcarnitine (m/z 400.341, RT 2.952 min). (D to G) Statistically significant metabolites altered by infection in lung tissue. (D) Hemin cation (m/z 616.175 RT 2.776 min) statistically significant at positions 3, 4, 9, and 10 (Wilcoxon FDR-corrected P value, <0.05). (E) Citrulline (m/z 198.085, RT 0.309 min) statistically significant at all positions (Wilcoxon FDR-corrected P value, <0.05) except position 12. (F) 4-Hydroxynonenal (m/z 139.112, RT 2.644 min) statistically significant at all positions (Wilcoxon FDR-corrected P value, <0.05) except positions 2, 5, and 12. (G) Spermidine (m/z 146.165, RT 0.287 min) statistically significant at all positions (Wilcoxon FDR-corrected P value, <0.05) except positions 10 and 12.