Figure 1.

Ptf1a enhancer deletion in mice causes pancreatic hypoplasia and diabetes

(A) Human PTF1A locus and ECR Browser conservation tracks. Sequences with >70% similarity over 100 bp in pairwise alignments are identified by horizontal pink lines on top of each track. The location of the mouse Ptf1a^enhP deletion is shown below.

(B and C) (B) Body weight and (C) pancreas weight (expressed as percentage of body weight) in 6- to 11-week-old mice (n = 22 each genotype, Student’s t test p values).

(D) Ad libitum glycemia of male mice after weaning (n = 22 each genotype).

(E) Basal and post-fed plasma insulin from 7-week-old male mice (n = 7 each genotype) after an overnight fast. (D) and (E) show means ± SEM. Student’s t test. ^∗∗∗p ≤ 0.0001, ^∗∗∗∗p ≤ 0.00001. See also Figure S1.