FIG 3.

Overview of vancomycin biosynthesis pathway labeled with genes significantly more abundant in hypolith compared with biocrust microbial communities. Schematic represents all major steps in the pathway, including synthesis of nonproteinogenic amino acids 4-Hydroxyphenlglycine (Hpg) and 3,5-Dihydroxyphenylglycine (Dpg), sugar biosynthesis, assembly of the peptide backbone via nonribosomal proteins synthesis, cross-linking and modification, and sugar attachment. Genes significantly more abundant in hypoliths (P < 0.01) are indicated by bold text. KEGG orthology numbers corresponding to genes names are in Table S6.