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. 2022 Jul 12;13(4):e01454-22. doi: 10.1128/mbio.01454-22

FIG 2.

FIG 2

Disease phenotypes after SARS-CoV MA15 infection in the CC011xCC074-F2 mice. The 10-to 12-week-old CC011xCC074-F2 mice (n = 403; 226 males, 177 females) were generated and infected with 1 × 104 PFU of SARS-CoV MA15 and followed for 4 days to record clinical disease outcomes. (A) Congestion score of CC011xCC074-F2 mice at 4 dpi. (B) Weight loss of CC011xCC074-F2 mice. (C) Lung viral titer of CC011xCC074-F2 mice at 4 dpi. (D) Percentage survival of CC011xCC074-F2 mice over the time of infection. (E) Percentage of peripheral blood lymphocytes of CC011xCC074-F2 mice at 4 dpi. (F) Percentage of peripheral blood neutrophils of CC011xCC074-F2 mice at 4 dpi. (G) PenH (airway resistance) of CC011xCC074-F2 mice at 2 dpi.